Metabolic engineering to improve 5-aminolevulinic acid production
نویسندگان
چکیده
منابع مشابه
Engineering Corynebacterium glutamicum to produce 5-aminolevulinic acid from glucose
BACKGROUND Corynebacterium glutamicum is generally regarded as a safe microorganism and is used to produce many biochemicals, including L-glutamate. 5-Aminolevulinic acid (ALA) is an L-glutamate derived non-protein amino acid, and is widely applied in fields such as medicine and agriculture. RESULTS The products of the gltX, hemA, and hemL genes participate in the synthesis of ALA from L-glut...
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متن کامل5-Aminolevulinic acid synthesis in Escherichia coli.
A hemA mutant of Escherichia coli containing a multicopy plasmid which complemented the mutation excreted 5-aminolevulinic acid (ALA) into the medium. [1-14C]glutamate was substantially incorporated into ALA by this strain, whereas [2-14C]glycine was not. Periodate degradation of labeled ALA showed that C-5 of ALA was derived from C-1 of glutamate. The synthesis of ALA by two sonicate fractions...
متن کاملMetabolic engineering of Corynebacterium glutamicum for enhanced production of 5-aminovaleric acid
BACKGROUND 5-Aminovaleric acid (5AVA) is an important five-carbon platform chemical that can be used for the synthesis of polymers and other chemicals of industrial interest. Enzymatic conversion of L-lysine to 5AVA has been achieved by employing lysine 2-monooxygenase encoded by the davB gene and 5-aminovaleramidase encoded by the davA gene. Additionally, a recombinant Escherichia coli strain ...
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ژورنال
عنوان ژورنال: Bioengineered Bugs
سال: 2011
ISSN: 1949-1018,1949-1026
DOI: 10.4161/bbug.2.6.17237